Which of the following is a characteristic of benign neoplasms?

Benign neoplasms are typically characterized by their innocuous gross and microscopic appearance as well as their localized nature. The term "benign" itself signifies that these tumors do not have the aggressive behaviors often associated with malignancies. Unlike malignant tumors, benign neoplasms do not invade surrounding tissues or metastasize to distant sites; they remain well-defined and grow slowly, often encapsulated by a fibrous capsule, which further limits their growth to a localized region.

Their microscopic features usually exhibit a well-differentiated structure, with cells resembling normal cells of the tissue from which they arise. This can include clear boundaries and a lack of significant cellular atypia, which is indicative of less aggressive biological behavior. Therefore, the correct answer emphasizes that benign neoplasms present a non-threatening appearance both to the naked eye and under microscopic examination while being confined to a specific area.